Motorists are facing long queues in both directions on the A505 Royston Road due to roadworks.
Vehicles travelling eastbound on the A505 will see queues of over a mile.
Two-way traffic control signals are in place until April 13 at 23.59pm, and continued delays are likely.
Cambridgeshire Traffic and Travel said: "There are delays due to temporary traffic lights in place for works by Cambridge Water. Queues of over a mile travelling eastbound. Please allow extra time for your journey."
Cambridge Water said: "Please accept our apologies for the delay in your journeys while to the works taking place at this time."
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